Assay Detail
Binding
CHEMBL927702
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Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HEK293 cells
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.16 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL23038 | — | — | 1 | 9.00 |
| CHEMBL431298 | — | — | 1 | 9.00 |
| CHEMBL95136 | — | — | 1 | 8.85 |
| CHEMBL76237 | — | — | 1 | 8.64 |
| CHEMBL329383 | — | — | 1 | 8.52 |
| CHEMBL401970 | — | — | 1 | 8.04 |
| CHEMBL253708 | — | — | 1 | 7.91 |
| CHEMBL253095 | — | — | 1 | 7.55 |
| CHEMBL404352 | — | — | 1 | 7.52 |
| CHEMBL254298 | — | — | 1 | 7.26 |
| CHEMBL433461 | — | — | 1 | 7.26 |
| CHEMBL251857 | — | — | 1 | 7.13 |
| CHEMBL253718 | — | — | 1 | 7.11 |
| CHEMBL253096 | — | — | 1 | 7.08 |
| CHEMBL253502 | — | — | 1 | 6.83 |
| CHEMBL253709 | — | — | 1 | 6.81 |
| CHEMBL252673 | — | — | 1 | 6.71 |
| CHEMBL401969 | — | — | 1 | 6.59 |
| CHEMBL254330 | — | — | 1 | 6.53 |
| CHEMBL403843 | — | — | 1 | 6.52 |
| CHEMBL252902 | — | — | 1 | 6.46 |
| CHEMBL402810 | — | — | 1 | 6.46 |
| CHEMBL46071 | — | — | 1 | 6.29 |
| CHEMBL251861 | — | — | 1 | 6.15 |
| CHEMBL404552 | — | — | 1 | 6.14 |
| CHEMBL252496 | — | — | 1 | 6.06 |
| CHEMBL254331 | — | — | 1 | 6.05 |
| CHEMBL253061 | — | — | 1 | 6.02 |
| CHEMBL404538 | — | — | 1 | - |
| CHEMBL253097 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL23038 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL431298 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL95136 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL76237 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL329383 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL401970 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL253708 | — | Ki | = | 12.3 | nM | 7.91 |
| CHEMBL253095 | — | Ki | = | 28.3 | nM | 7.55 |
| CHEMBL404352 | — | Ki | = | 30.1 | nM | 7.52 |
| CHEMBL433461 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL254298 | — | Ki | = | 54.7 | nM | 7.26 |
| CHEMBL251857 | — | Ki | = | 73.2 | nM | 7.13 |
| CHEMBL253718 | — | Ki | = | 77.5 | nM | 7.11 |
| CHEMBL253096 | — | Ki | = | 82.4 | nM | 7.08 |
| CHEMBL253502 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL253709 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL252673 | — | Ki | = | 196.9 | nM | 6.71 |
| CHEMBL401969 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL254330 | — | Ki | = | 293.0 | nM | 6.53 |
| CHEMBL403843 | — | Ki | = | 304.0 | nM | 6.52 |
| CHEMBL252902 | — | Ki | = | 346.0 | nM | 6.46 |
| CHEMBL402810 | — | Ki | = | 344.6 | nM | 6.46 |
| CHEMBL46071 | — | Ki | = | 512.0 | nM | 6.29 |
| CHEMBL251861 | — | Ki | = | 715.0 | nM | 6.15 |
| CHEMBL404552 | — | Ki | = | 728.0 | nM | 6.14 |
| CHEMBL252496 | — | Ki | = | 877.0 | nM | 6.06 |
| CHEMBL254331 | — | Ki | = | 893.0 | nM | 6.05 |
| CHEMBL253061 | — | Ki | = | 952.0 | nM | 6.02 |
| CHEMBL404538 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL253097 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL253513 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL402292 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL402380 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL253271 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL253281 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL401707 | — | Ki | > | 1000.0 | nM | - |