Assay Detail
Binding
CHEMBL927706
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Displacement of [3H]LSD from human cloned 5HT7 receptor
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.40 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431298 | — | — | 1 | 6.58 |
| CHEMBL253096 | — | — | 1 | 6.22 |
| CHEMBL253708 | — | — | 1 | - |
| CHEMBL404352 | — | — | 1 | - |
| CHEMBL254298 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431298 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL253096 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL253708 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL404352 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL254298 | — | Ki | > | 10000.0 | nM | - |