Assay Detail
Binding
CHEMBL927768
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Inhibition of HDAC8
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Optimization of biaryl Selective HDAC1&2 Inhibitors (SHI-1:2).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.25 | 6.39 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.39 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 4.85 |
| CHEMBL235674 | — | — | 1 | 4.50 |
| CHEMBL398420 | — | — | 1 | - |
| CHEMBL399494 | — | — | 1 | - |
| CHEMBL400721 | — | — | 1 | - |
| CHEMBL253868 | — | — | 1 | - |
| CHEMBL398884 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 14120.0 | nM | 4.85 |
| CHEMBL235674 | — | IC50 | = | 31738.0 | nM | 4.50 |
| CHEMBL398420 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL399494 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL400721 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL253868 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL398884 | — | Activity | - | — | - |