Assay Detail
Functional
CHEMBL928090
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Antimalarial activity against Plasmodium falciparum 3D7
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Two-step synthesis of achiral dispiro-1,2,4,5-tetraoxanes with outstanding antimalarial activity, low toxicity, and high-stability profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.84 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207675 | SODIUM ARESUNATE | — | 1 | 9.22 |
| CHEMBL566534 | ARTEMETHER | 4.0 | 1 | 8.49 |
| CHEMBL405944 | — | — | 1 | 8.45 |
| CHEMBL259023 | — | — | 1 | 8.33 |
| CHEMBL406928 | — | — | 1 | 8.30 |
| CHEMBL410640 | — | — | 1 | 8.26 |
| CHEMBL261818 | — | — | 1 | 8.26 |
| CHEMBL261816 | — | — | 1 | 8.23 |
| CHEMBL269671 | ARTEMISININ | 3.0 | 1 | 8.04 |
| CHEMBL402472 | — | — | 1 | 7.99 |
| CHEMBL260683 | — | — | 1 | 7.84 |
| CHEMBL261066 | — | — | 1 | 7.80 |
| CHEMBL409431 | — | — | 1 | 7.78 |
| CHEMBL258908 | — | — | 1 | 7.68 |
| CHEMBL258763 | — | — | 1 | 7.64 |
| CHEMBL258875 | — | — | 1 | 7.56 |
| CHEMBL436908 | — | — | 1 | 7.54 |
| CHEMBL405885 | — | — | 1 | 7.22 |
| CHEMBL430041 | — | — | 1 | 7.06 |
| CHEMBL405884 | — | — | 1 | 6.88 |
| CHEMBL261500 | — | — | 1 | 6.15 |
| CHEMBL405890 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207675 | SODIUM ARESUNATE | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL566534 | ARTEMETHER | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL405944 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL259023 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL406928 | — | IC50 | = | 4.98 | nM | 8.30 |
| CHEMBL410640 | — | IC50 | = | 5.46 | nM | 8.26 |
| CHEMBL261818 | — | IC50 | = | 5.55 | nM | 8.26 |
| CHEMBL261816 | — | IC50 | = | 5.87 | nM | 8.23 |
| CHEMBL269671 | ARTEMISININ | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL402472 | — | IC50 | = | 10.18 | nM | 7.99 |
| CHEMBL260683 | — | IC50 | = | 14.35 | nM | 7.84 |
| CHEMBL261066 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL409431 | — | IC50 | = | 16.73 | nM | 7.78 |
| CHEMBL258908 | — | IC50 | = | 20.73 | nM | 7.68 |
| CHEMBL258763 | — | IC50 | = | 22.73 | nM | 7.64 |
| CHEMBL258875 | — | IC50 | = | 27.75 | nM | 7.56 |
| CHEMBL436908 | — | IC50 | = | 29.13 | nM | 7.54 |
| CHEMBL405885 | — | IC50 | = | 60.57 | nM | 7.22 |
| CHEMBL430041 | — | IC50 | = | 86.37 | nM | 7.06 |
| CHEMBL405884 | — | IC50 | = | 131.07 | nM | 6.88 |
| CHEMBL261500 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL405890 | — | IC50 | > | 1000.0 | nM | - |