Assay Detail
Binding
CHEMBL928167
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Inhibition of KDR in presence of 1 mM ATP
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.48 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260092 | — | — | 1 | 8.52 |
| CHEMBL411903 | — | — | 1 | 8.40 |
| CHEMBL429516 | — | — | 1 | 8.30 |
| CHEMBL403706 | — | — | 1 | 8.22 |
| CHEMBL412102 | — | — | 1 | 8.22 |
| CHEMBL409872 | — | — | 1 | 7.72 |
| CHEMBL410731 | — | — | 1 | 7.31 |
| CHEMBL262607 | — | — | 1 | 7.19 |
| CHEMBL259013 | — | — | 1 | 6.96 |
| CHEMBL260848 | — | — | 1 | 6.90 |
| CHEMBL263374 | — | — | 1 | 6.05 |
| CHEMBL260093 | — | — | 1 | 6.02 |
| CHEMBL409839 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260092 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL411903 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL429516 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL403706 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL412102 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL409872 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL410731 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL262607 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL259013 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL260848 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL263374 | — | IC50 | = | 888.0 | nM | 6.05 |
| CHEMBL260093 | — | IC50 | = | 951.0 | nM | 6.02 |
| CHEMBL409839 | — | IC50 | > | 13000.0 | nM | - |