Assay Detail
Binding
CHEMBL928168
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Inhibition of VEGF-induced KDR phosphorylation in mouse 3T3 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL3337) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.72 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL260092 | — | — | 1 | 7.89 |
| CHEMBL412102 | — | — | 1 | 7.31 |
| CHEMBL409872 | — | — | 1 | 7.30 |
| CHEMBL403706 | — | — | 1 | 7.28 |
| CHEMBL411903 | — | — | 1 | 6.92 |
| CHEMBL262607 | — | — | 1 | 6.51 |
| CHEMBL429516 | — | — | 1 | 6.46 |
| CHEMBL260848 | — | — | 1 | 6.10 |
| CHEMBL410731 | — | — | 1 | 5.82 |
| CHEMBL259013 | — | — | 1 | 5.61 |
| CHEMBL260093 | — | — | 1 | - |
| CHEMBL409839 | — | — | 1 | - |
| CHEMBL263374 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL260092 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL412102 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL409872 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL403706 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL411903 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL262607 | — | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL429516 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL260848 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL410731 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL259013 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL260093 | — | IC50 | - | — | - | |
| CHEMBL409839 | — | IC50 | - | — | - | |
| CHEMBL263374 | — | IC50 | - | — | - |