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Assay Detail

CHEMBL928315

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human recombinant ACE2 by fluorescence assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Angiotensin-converting enzyme 2 (CHEMBL3736)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Thiol-based angiotensin-converting enzyme 2 inhibitors: P1' modifications for the exploration of the S1' subsite.
Deaton DN, Graham KP, Gross JW, Miller AB.
Bioorg Med Chem Lett (2008) 18 : 1681 -1687
PubMed 18243695 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 8.35 9.07

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL251808 1 9.07
CHEMBL251804 1 9.05
CHEMBL253224 1 8.89
CHEMBL252391 1 8.82
CHEMBL400526 1 8.82
CHEMBL398771 1 8.70
CHEMBL254282 1 8.66
CHEMBL400527 1 8.66
CHEMBL401397 1 8.66
CHEMBL253428 1 8.62
CHEMBL254495 1 8.62
CHEMBL254911 1 8.60
CHEMBL254703 1 8.57
CHEMBL252003 1 8.24
CHEMBL254493 1 8.22
CHEMBL254900 1 7.85
CHEMBL251809 1 7.46
CHEMBL398545 1 7.43
CHEMBL252009 1 7.08
CHEMBL401086 1 7.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL251808 Ki = 0.85 nM 9.07
CHEMBL251804 Ki = 0.9 nM 9.05
CHEMBL253224 Ki = 1.3 nM 8.89
CHEMBL252391 Ki = 1.5 nM 8.82
CHEMBL400526 Ki = 1.5 nM 8.82
CHEMBL398771 Ki = 2.0 nM 8.70
CHEMBL254282 Ki = 2.2 nM 8.66
CHEMBL400527 Ki = 2.2 nM 8.66
CHEMBL401397 Ki = 2.2 nM 8.66
CHEMBL253428 Ki = 2.4 nM 8.62
CHEMBL254495 Ki = 2.4 nM 8.62
CHEMBL254911 Ki = 2.5 nM 8.60
CHEMBL254703 Ki = 2.7 nM 8.57
CHEMBL252003 Ki = 5.8 nM 8.24
CHEMBL254493 Ki = 6.0 nM 8.22
CHEMBL254900 Ki = 14.0 nM 7.85
CHEMBL251809 Ki = 35.0 nM 7.46
CHEMBL398545 Ki = 37.0 nM 7.43
CHEMBL252009 Ki = 84.0 nM 7.08
CHEMBL401086 Ki = 90.0 nM 7.05