Assay Detail
Binding
CHEMBL928488
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt2 in human C33A cells by immunoprecipitation kinase assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | C-33-A |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of pyridopyrimidines as potent Akt1/2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.85 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL253458 | — | — | 1 | 6.33 |
| CHEMBL404555 | — | — | 1 | 6.23 |
| CHEMBL254099 | — | — | 1 | 6.23 |
| CHEMBL404554 | — | — | 1 | 6.20 |
| CHEMBL253693 | — | — | 1 | 6.08 |
| CHEMBL252857 | — | — | 1 | 6.05 |
| CHEMBL252856 | — | — | 1 | 5.95 |
| CHEMBL403356 | — | — | 1 | 5.80 |
| CHEMBL253457 | — | — | 1 | 5.74 |
| CHEMBL404347 | — | — | 1 | 5.64 |
| CHEMBL404556 | — | — | 1 | 5.43 |
| CHEMBL252652 | — | — | 1 | 5.28 |
| CHEMBL252457 | — | — | 1 | 5.03 |
| CHEMBL404553 | — | — | 1 | - |
| CHEMBL252654 | — | — | 1 | - |
| CHEMBL252653 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL253458 | — | IC50 | = | 468.0 | nM | 6.33 |
| CHEMBL404555 | — | IC50 | = | 586.0 | nM | 6.23 |
| CHEMBL254099 | — | IC50 | = | 589.0 | nM | 6.23 |
| CHEMBL404554 | — | IC50 | = | 635.0 | nM | 6.20 |
| CHEMBL253693 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL252857 | — | IC50 | = | 899.0 | nM | 6.05 |
| CHEMBL252856 | — | IC50 | = | 1131.0 | nM | 5.95 |
| CHEMBL403356 | — | IC50 | = | 1572.0 | nM | 5.80 |
| CHEMBL253457 | — | IC50 | = | 1811.0 | nM | 5.74 |
| CHEMBL404347 | — | IC50 | = | 2295.0 | nM | 5.64 |
| CHEMBL404556 | — | IC50 | = | 3706.0 | nM | 5.43 |
| CHEMBL252652 | — | IC50 | = | 5296.0 | nM | 5.28 |
| CHEMBL252457 | — | IC50 | = | 9259.0 | nM | 5.03 |
| CHEMBL404553 | — | IC50 | - | — | - | |
| CHEMBL252654 | — | IC50 | - | — | - | |
| CHEMBL252653 | — | IC50 | - | — | - |