Assay Detail
Binding
CHEMBL928490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Akt2
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
RAC-beta serine/threonine-protein kinase (CHEMBL2431) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of pyridopyrimidines as potent Akt1/2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.31 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254099 | — | — | 1 | 7.58 |
| CHEMBL404556 | — | — | 1 | 7.46 |
| CHEMBL253693 | — | — | 1 | 7.36 |
| CHEMBL404554 | — | — | 1 | 7.24 |
| CHEMBL404555 | — | — | 1 | 7.23 |
| CHEMBL252456 | — | — | 1 | 7.05 |
| CHEMBL252857 | — | — | 1 | 7.03 |
| CHEMBL253458 | — | — | 1 | 7.00 |
| CHEMBL404347 | — | — | 1 | 6.97 |
| CHEMBL253457 | — | — | 1 | 6.62 |
| CHEMBL403356 | — | — | 1 | 6.57 |
| CHEMBL252856 | — | — | 1 | 6.52 |
| CHEMBL252261 | — | — | 1 | 6.31 |
| CHEMBL252455 | — | — | 1 | 6.28 |
| CHEMBL252457 | — | — | 1 | 6.03 |
| CHEMBL403354 | — | — | 1 | 5.94 |
| CHEMBL252054 | — | — | 1 | 5.91 |
| CHEMBL276130 | — | — | 1 | 5.89 |
| CHEMBL404553 | — | — | 1 | 5.88 |
| CHEMBL252056 | — | — | 1 | 5.86 |
| CHEMBL252259 | — | — | 1 | 5.82 |
| CHEMBL252055 | — | — | 1 | 5.77 |
| CHEMBL403355 | — | — | 1 | 5.75 |
| CHEMBL252652 | — | — | 1 | 5.72 |
| CHEMBL252653 | — | — | 1 | 5.68 |
| CHEMBL252654 | — | — | 1 | 5.29 |
| CHEMBL251860 | — | — | 1 | 5.05 |
| CHEMBL252260 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254099 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL404556 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL253693 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL404554 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL404555 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL252456 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL252857 | — | IC50 | = | 94.4 | nM | 7.03 |
| CHEMBL253458 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL404347 | — | IC50 | = | 107.2 | nM | 6.97 |
| CHEMBL253457 | — | IC50 | = | 239.0 | nM | 6.62 |
| CHEMBL403356 | — | IC50 | = | 267.0 | nM | 6.57 |
| CHEMBL252856 | — | IC50 | = | 301.0 | nM | 6.52 |
| CHEMBL252261 | — | IC50 | = | 494.0 | nM | 6.31 |
| CHEMBL252455 | — | IC50 | = | 529.0 | nM | 6.28 |
| CHEMBL252457 | — | IC50 | = | 928.0 | nM | 6.03 |
| CHEMBL403354 | — | IC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL252054 | — | IC50 | = | 1242.0 | nM | 5.91 |
| CHEMBL276130 | — | IC50 | = | 1299.0 | nM | 5.89 |
| CHEMBL404553 | — | IC50 | = | 1304.0 | nM | 5.88 |
| CHEMBL252056 | — | IC50 | = | 1381.0 | nM | 5.86 |
| CHEMBL252259 | — | IC50 | = | 1514.0 | nM | 5.82 |
| CHEMBL252055 | — | IC50 | = | 1709.0 | nM | 5.77 |
| CHEMBL403355 | — | IC50 | = | 1792.0 | nM | 5.75 |
| CHEMBL252652 | — | IC50 | = | 1909.0 | nM | 5.72 |
| CHEMBL252653 | — | IC50 | = | 2106.0 | nM | 5.68 |
| CHEMBL252654 | — | IC50 | = | 5127.0 | nM | 5.29 |
| CHEMBL251860 | — | IC50 | = | 8923.0 | nM | 5.05 |
| CHEMBL252260 | — | IC50 | = | 17470.0 | nM | 4.76 |