Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL928514

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antagonist activity at human CCR2b receptor
ChEMBL ↗
94
Total Activities
47
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

C-C chemokine receptor type 2 (CHEMBL4015) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

QSAR studies on CCR2 antagonists with chiral sensitive hologram descriptors.
Nair PC, Srikanth K, Sobhia ME.
Bioorg Med Chem Lett (2008) 18 : 1323 -1330
PubMed 18258426 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 94 7.31 9.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL230281 — — 2 9.37
CHEMBL397996 — — 2 8.74
CHEMBL437359 — — 2 8.72
CHEMBL230933 — — 2 8.51
CHEMBL231246 — — 2 8.46
CHEMBL397997 — — 2 8.46
CHEMBL231039 — — 2 8.41
CHEMBL230722 — — 2 8.40
CHEMBL230721 — — 2 8.12
CHEMBL398000 — — 2 8.10
CHEMBL230617 — — 2 8.05
CHEMBL230832 — — 2 7.89
CHEMBL389773 — — 2 7.88
CHEMBL230507 — — 2 7.88
CHEMBL252412 — — 2 7.85
CHEMBL397750 — — 2 7.84
CHEMBL387587 — — 2 7.80
CHEMBL230405 — — 2 7.72
CHEMBL230616 — — 2 7.70
CHEMBL400517 — — 2 7.60
CHEMBL252611 — — 2 7.55
CHEMBL388675 — — 2 7.55
CHEMBL398150 — — 2 7.52
CHEMBL211775 — — 2 7.41
CHEMBL388949 — — 2 7.38
CHEMBL231247 — — 2 7.17
CHEMBL215654 — — 2 7.01
CHEMBL252815 — — 2 6.90
CHEMBL409162 — — 2 6.76
CHEMBL210606 — — 2 6.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL230281 — IC50 = 0.4266 nM 9.37
CHEMBL230281 — IC50 = 0.43 nM 9.37
CHEMBL397996 — IC50 = 1.8 nM 8.74
CHEMBL397996 — IC50 = 1.82 nM 8.74
CHEMBL437359 — IC50 = 1.9 nM 8.72
CHEMBL437359 — IC50 = 1.905 nM 8.72
CHEMBL230933 — IC50 = 3.1 nM 8.51
CHEMBL230933 — IC50 = 3.09 nM 8.51
CHEMBL231246 — IC50 = 3.467 nM 8.46
CHEMBL397997 — IC50 = 3.5 nM 8.46
CHEMBL231246 — IC50 = 3.5 nM 8.46
CHEMBL397997 — IC50 = 3.467 nM 8.46
CHEMBL231039 — IC50 = 3.9 nM 8.41
CHEMBL231039 — IC50 = 3.89 nM 8.41
CHEMBL230722 — IC50 = 3.981 nM 8.40
CHEMBL230722 — IC50 = 4.0 nM 8.40
CHEMBL230721 — IC50 = 7.586 nM 8.12
CHEMBL230721 — IC50 = 7.6 nM 8.12
CHEMBL398000 — IC50 = 8.0 nM 8.10
CHEMBL398000 — IC50 = 7.943 nM 8.10
CHEMBL230617 — IC50 = 8.913 nM 8.05
CHEMBL230617 — IC50 = 9.0 nM 8.05
CHEMBL230832 — IC50 = 13.0 nM 7.89
CHEMBL230832 — IC50 = 12.88 nM 7.89
CHEMBL389773 — IC50 = 13.18 nM 7.88
CHEMBL230507 — IC50 = 13.18 nM 7.88
CHEMBL230507 — IC50 = 13.3 nM 7.88
CHEMBL389773 — IC50 = 13.3 nM 7.88
CHEMBL252412 — IC50 = 14.0 nM 7.85
CHEMBL252412 — IC50 = 14.13 nM 7.85
CHEMBL397750 — IC50 = 14.45 nM 7.84
CHEMBL397750 — IC50 = 14.3 nM 7.84
CHEMBL387587 — IC50 = 15.85 nM 7.80
CHEMBL387587 — IC50 = 16.0 nM 7.80
CHEMBL230405 — IC50 = 19.05 nM 7.72
CHEMBL230405 — IC50 = 19.0 nM 7.72
CHEMBL230616 — IC50 = 19.95 nM 7.70
CHEMBL230616 — IC50 = 20.0 nM 7.70
CHEMBL400517 — IC50 = 25.0 nM 7.60
CHEMBL400517 — IC50 = 25.12 nM 7.60
CHEMBL252611 — IC50 = 28.18 nM 7.55
CHEMBL252611 — IC50 = 28.0 nM 7.55
CHEMBL388675 — IC50 = 28.18 nM 7.55
CHEMBL388675 — IC50 = 28.0 nM 7.55
CHEMBL398150 — IC50 = 30.2 nM 7.52
CHEMBL398150 — IC50 = 30.0 nM 7.52
CHEMBL211775 — IC50 = 39.0 nM 7.41
CHEMBL211775 — IC50 = 38.9 nM 7.41
CHEMBL388949 — IC50 = 41.69 nM 7.38
CHEMBL388949 — IC50 = 42.0 nM 7.38