Assay Detail
Binding
CHEMBL928532
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of KDR
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.55 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL153843 | — | — | 1 | 7.41 |
| CHEMBL253429 | — | — | 1 | 6.42 |
| CHEMBL254704 | — | — | 1 | 6.19 |
| CHEMBL254494 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL153843 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL253429 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL254704 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL254494 | — | IC50 | = | 700.0 | nM | 6.16 |