Assay Detail
Binding
CHEMBL928702
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Inhibition of human mu-calpain
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Design and synthesis of 4-quinolinone 2-carboxamides as calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.67 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL195728 | — | — | 1 | 7.40 |
| CHEMBL423112 | — | — | 1 | 7.16 |
| CHEMBL254142 | — | — | 1 | 6.15 |
| CHEMBL253315 | — | — | 1 | 6.14 |
| CHEMBL253112 | — | — | 1 | 5.75 |
| CHEMBL401986 | — | — | 1 | 5.43 |
| CHEMBL401985 | — | — | 1 | 5.42 |
| CHEMBL253111 | — | — | 1 | 5.30 |
| CHEMBL253113 | — | — | 1 | 5.25 |
| CHEMBL253316 | — | — | 1 | 5.20 |
| CHEMBL253314 | — | — | 1 | 5.11 |
| CHEMBL254948 | — | — | 1 | 5.06 |
| CHEMBL254949 | — | — | 1 | 4.40 |
| CHEMBL402385 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL195728 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL423112 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL254142 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL253315 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL253112 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL401986 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL401985 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL253111 | — | IC50 | = | 5010.0 | nM | 5.30 |
| CHEMBL253113 | — | IC50 | = | 5630.0 | nM | 5.25 |
| CHEMBL253316 | — | IC50 | = | 6280.0 | nM | 5.20 |
| CHEMBL253314 | — | IC50 | = | 7720.0 | nM | 5.11 |
| CHEMBL254948 | — | IC50 | = | 8620.0 | nM | 5.06 |
| CHEMBL254949 | — | IC50 | = | 40170.0 | nM | 4.40 |
| CHEMBL402385 | — | IC50 | > | 50000.0 | nM | - |