Assay Detail

CHEMBL928780

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Functional

Induction of contraction in beta-estradiol stimulated rat myometrium

ChEMBL ↗

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Target

Myometrium (CHEMBL613647) ↗

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Primary target Myometrium

CHEMBL613647

Anchored from Assay target.

Protein identity Myometrium

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Rattus norvegicus
Tissue	Myometrium
Confidence	1 — Organism
Curated By	Autocuration

Target

Myometrium (CHEMBL613647) ↗

Type	TISSUE
Organism	Rattus norvegicus

Publication

Synthesis and pharmacological evaluation of a new targeted drug carrier system: beta-cyclodextrin coupled to oxytocin.

Bertolla C, Rolin S, Evrard B, Pochet L, Masereel B.
Bioorg Med Chem Lett (2008) 18 : 1855 -1858
PubMed 18296049 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	7.59	8.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL395429	OXYTOCIN	4.0	1	8.77
CHEMBL254371	—	—	1	6.40

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL395429	OXYTOCIN	EC50	=	1.7	nM	8.77
CHEMBL254371	—	EC50	=	400.0	nM	6.40