Assay Detail

CHEMBL928846

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of human chymotrypsin

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Structure-activity relationship and pharmacokinetic profile of 5-ketopyrazole factor Xa inhibitors.

Varnes JG, Wacker DA, Pinto DJ, Orwat MJ, Theroff JP, Wells B, Galemo RA, Luettgen JM, Knabb RM, Bai S, He K, Lam PY, Wexler RR.
Bioorg Med Chem Lett (2008) 18 : 749 -754
PubMed 18054227 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	5.77	5.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL403042	—	—	1	5.77
CHEMBL206335	RAZAXABAN	2.0	1	-

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL403042	—	Ki	=	1700.0	nM	5.77
CHEMBL206335	RAZAXABAN	Ki	>	8500.0	nM	-