Assay Detail
Binding
CHEMBL928873
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Inhibition of CDK2
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Identification of 2-amino-5-(thioaryl)thiazoles as inhibitors of nerve growth factor receptor TrkA.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.45 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254269 | — | — | 1 | 6.75 |
| CHEMBL251796 | — | — | 1 | 6.64 |
| CHEMBL254050 | — | — | 1 | 6.31 |
| CHEMBL251795 | — | — | 1 | 6.28 |
| CHEMBL254895 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254269 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL251796 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL254050 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL251795 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL254895 | — | IC50 | = | 540.0 | nM | 6.27 |