Assay Detail
Functional
CHEMBL928951
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Antiproliferative activity against human SNU638 cells after 72 hrs by SRB assay
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SNU-638 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.85 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.16 |
| CHEMBL578357 | SCHISANTHERIN C | — | 1 | 4.82 |
| CHEMBL253688 | SCHIZANDRIN | — | 1 | 4.68 |
| CHEMBL402435 | WUWEIZISU B | — | 2 | 4.64 |
| CHEMBL404875 | GOMISIN C | — | 1 | 4.35 |
| CHEMBL253908 | SCHISANDRIN A | — | 1 | 4.28 |
| CHEMBL1159658 | GOMISIN A | — | 1 | 4.04 |
| CHEMBL251864 | GOMISIN J | — | 1 | - |
| CHEMBL437412 | SCHISANDRIN C | — | 1 | - |
| CHEMBL253687 | GOMISIN B | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL578357 | SCHISANTHERIN C | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL253688 | SCHIZANDRIN | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL402435 | WUWEIZISU B | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL404875 | GOMISIN C | IC50 | = | 44700.0 | nM | 4.35 |
| CHEMBL253908 | SCHISANDRIN A | IC50 | = | 53100.0 | nM | 4.28 |
| CHEMBL1159658 | GOMISIN A | IC50 | = | 90500.0 | nM | 4.04 |
| CHEMBL251864 | GOMISIN J | IC50 | > | 100000.0 | nM | - |
| CHEMBL402435 | WUWEIZISU B | IC50 | > | 100000.0 | nM | - |
| CHEMBL437412 | SCHISANDRIN C | IC50 | > | 100000.0 | nM | - |
| CHEMBL253687 | GOMISIN B | IC50 | > | 100000.0 | nM | - |