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Assay Detail

CHEMBL928968

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Binding
Inhibition of human p38beta
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Intermediate

Target

Mitogen-activated protein kinase 11 (CHEMBL3961)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

The discovery of (R)-2-(sec-butylamino)-N-(2-methyl-5-(methylcarbamoyl)phenyl) thiazole-5-carboxamide (BMS-640994)-A potent and efficacious p38alpha MAP kinase inhibitor.
Hynes J, Wu H, Pitt S, Shen DR, Zhang R, Schieven GL, Gillooly KM, Shuster DJ, Taylor TL, Yang X, McIntyre KW, McKinnon M, Zhang H, Marathe PH, Doweyko AM, Kish K, Kiefer SE, Sack JS, Newitt JA, Barrish JC, Dodd J, Leftheris K.
Bioorg Med Chem Lett (2008) 18 : 1762 -1767
PubMed 18313298 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 8.82 8.82

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL258202 1 8.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL258202 IC50 = 1.5 nM 8.82