Assay Detail
Binding
CHEMBL929004
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Inhibition of CDK4
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.81 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257831 | — | — | 1 | 6.68 |
| CHEMBL255262 | — | — | 1 | 6.15 |
| CHEMBL258040 | — | — | 1 | 6.12 |
| CHEMBL255463 | — | — | 1 | 6.05 |
| CHEMBL404504 | — | — | 1 | 5.98 |
| CHEMBL415789 | — | — | 1 | 5.89 |
| CHEMBL254171 | — | — | 1 | 5.88 |
| CHEMBL254170 | — | — | 1 | 5.85 |
| CHEMBL254979 | — | — | 1 | 5.80 |
| CHEMBL255718 | — | — | 1 | 5.76 |
| CHEMBL256558 | — | — | 1 | 5.75 |
| CHEMBL402158 | — | — | 1 | 5.75 |
| CHEMBL402370 | — | — | 1 | 5.70 |
| CHEMBL402157 | — | — | 1 | 5.70 |
| CHEMBL255932 | — | — | 1 | 5.66 |
| CHEMBL402759 | — | — | 1 | 5.66 |
| CHEMBL254367 | — | — | 1 | 5.52 |
| CHEMBL255263 | — | — | 1 | 5.52 |
| CHEMBL255255 | — | — | 1 | 5.43 |
| CHEMBL403605 | — | — | 1 | 5.40 |
| CHEMBL258039 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257831 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL255262 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL258040 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL255463 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL404504 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL415789 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL254171 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL254170 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL254979 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL255718 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL256558 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL402158 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL402370 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL402157 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL255932 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL402759 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL254367 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL255263 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL255255 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL403605 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL258039 | — | IC50 | > | 1000.0 | nM | - |