Assay Detail
Functional
CHEMBL929010
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Antiproliferative activity against human SW620 cells after 48 hrs
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SW-620 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.22 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402759 | — | — | 1 | 7.40 |
| CHEMBL254979 | — | — | 1 | 7.10 |
| CHEMBL415789 | — | — | 1 | 6.82 |
| CHEMBL254367 | — | — | 1 | 6.03 |
| CHEMBL402157 | — | — | 1 | 6.03 |
| CHEMBL256558 | — | — | 1 | 5.81 |
| CHEMBL402370 | — | — | 1 | 5.70 |
| CHEMBL255255 | — | — | 1 | 5.66 |
| CHEMBL255718 | — | — | 1 | 5.42 |
| CHEMBL254171 | — | — | 1 | - |
| CHEMBL254170 | — | — | 1 | - |
| CHEMBL258040 | — | — | 1 | - |
| CHEMBL258039 | — | — | 1 | - |
| CHEMBL257831 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402759 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL254979 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL415789 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL254367 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL402157 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL256558 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL402370 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL255255 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL255718 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL254171 | — | IC50 | - | — | - | |
| CHEMBL254170 | — | IC50 | - | — | - | |
| CHEMBL258040 | — | IC50 | - | — | - | |
| CHEMBL258039 | — | IC50 | - | — | - | |
| CHEMBL257831 | — | IC50 | - | — | - |