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Assay Detail

CHEMBL929045

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes by microplate assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Intermediate

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.
Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A.
Bioorg Med Chem Lett (2008) 18 : 2272 -2276
PubMed 18353643 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.17 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL255732 1 6.55
CHEMBL125 MILTEFOSINE 4.0 1 6.51
CHEMBL255731 1 6.47
CHEMBL255729 1 6.46
CHEMBL255730 1 6.44
CHEMBL401810 1 6.33
CHEMBL255101 1 6.31
CHEMBL255944 1 6.29
CHEMBL255314 1 6.28
CHEMBL255512 1 6.26
CHEMBL255943 1 6.16
CHEMBL255946 1 6.04
CHEMBL256155 1 5.90
CHEMBL255942 1 5.88
CHEMBL255945 1 5.74
CHEMBL254950 1 5.64
CHEMBL254749 1 5.62

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL255732 IC50 = 280.0 nM 6.55
CHEMBL125 MILTEFOSINE IC50 = 310.0 nM 6.51
CHEMBL255731 IC50 = 340.0 nM 6.47
CHEMBL255729 IC50 = 350.0 nM 6.46
CHEMBL255730 IC50 = 360.0 nM 6.44
CHEMBL401810 IC50 = 470.0 nM 6.33
CHEMBL255101 IC50 = 490.0 nM 6.31
CHEMBL255944 IC50 = 510.0 nM 6.29
CHEMBL255314 IC50 = 530.0 nM 6.28
CHEMBL255512 IC50 = 550.0 nM 6.26
CHEMBL255943 IC50 = 700.0 nM 6.16
CHEMBL255946 IC50 = 920.0 nM 6.04
CHEMBL256155 IC50 = 1260.0 nM 5.90
CHEMBL255942 IC50 = 1320.0 nM 5.88
CHEMBL255945 IC50 = 1810.0 nM 5.74
CHEMBL254950 IC50 = 2290.0 nM 5.64
CHEMBL254749 IC50 = 2370.0 nM 5.62