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Assay Detail

CHEMBL929049

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Selectivity index, ratio of IC50 for rat L6 cells to IC50 for Leishmania donovani MHOM-ET-67/L82
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Cell Type L6
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis of a small library of 2-phenoxy-1,4-naphthoquinone and 2-phenoxy-1,4-anthraquinone derivatives bearing anti-trypanosomal and anti-leishmanial activity.
Bolognesi ML, Lizzi F, Perozzo R, Brun R, Cavalli A.
Bioorg Med Chem Lett (2008) 18 : 2272 -2276
PubMed 18353643 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.30 5.62

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL254950 1 5.62
CHEMBL255945 1 5.59
CHEMBL255731 1 5.53
CHEMBL255729 1 5.49
CHEMBL255942 1 5.41
CHEMBL255101 1 5.38
CHEMBL256155 1 5.33
CHEMBL401810 1 5.33
CHEMBL255314 1 5.30
CHEMBL255946 1 5.27
CHEMBL255943 1 5.18
CHEMBL255732 1 5.15
CHEMBL255730 1 5.15
CHEMBL255512 1 5.12
CHEMBL255944 1 4.99
CHEMBL254749 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL254950 IC50 = 2410.0 nM 5.62
CHEMBL255945 IC50 = 2580.0 nM 5.59
CHEMBL255731 IC50 = 2940.0 nM 5.53
CHEMBL255729 IC50 = 3240.0 nM 5.49
CHEMBL255942 IC50 = 3940.0 nM 5.41
CHEMBL255101 IC50 = 4150.0 nM 5.38
CHEMBL256155 IC50 = 4690.0 nM 5.33
CHEMBL401810 IC50 = 4710.0 nM 5.33
CHEMBL255314 IC50 = 5010.0 nM 5.30
CHEMBL255946 IC50 = 5340.0 nM 5.27
CHEMBL255943 IC50 = 6540.0 nM 5.18
CHEMBL255732 IC50 = 7010.0 nM 5.15
CHEMBL255730 IC50 = 7100.0 nM 5.15
CHEMBL255512 IC50 = 7530.0 nM 5.12
CHEMBL255944 IC50 = 10300.0 nM 4.99
CHEMBL254749 IC50 = 12100.0 nM 4.92