Assay Detail
Binding
CHEMBL929238
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Inhibition of human cathepsin B
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of trypanocidal thiosemicarbazone inhibitors of rhodesain and TbcatB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.64 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL407264 | — | — | 1 | 6.68 |
| CHEMBL260921 | — | — | 1 | 6.52 |
| CHEMBL259379 | — | — | 1 | 6.52 |
| CHEMBL404938 | — | — | 1 | 5.77 |
| CHEMBL261438 | — | — | 1 | 5.75 |
| CHEMBL410086 | — | — | 1 | 5.52 |
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | — | 1 | 5.48 |
| CHEMBL261307 | — | — | 1 | 5.35 |
| CHEMBL406601 | — | — | 1 | 5.31 |
| CHEMBL258588 | — | — | 1 | 5.22 |
| CHEMBL402465 | — | — | 1 | 4.89 |
| CHEMBL261218 | — | — | 1 | 4.66 |
| CHEMBL429858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL407264 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL260921 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL259379 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL404938 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL261438 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL410086 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL261657 | THIOSEMICARBAZONE STANDARD | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL261307 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL406601 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL258588 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL402465 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL261218 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL429858 | — | IC50 | > | 25000.0 | nM | - |