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Assay Detail

CHEMBL929266

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine carboxypeptidase A
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carboxypeptidase A1 (CHEMBL3481)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2.
Mores A, Matziari M, Beau F, Cuniasse P, Yiotakis A, Dive V.
J Med Chem (2008) 51 : 2216 -2226
PubMed 18324760 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 7 7.71 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL408705 1 9.52
CHEMBL260273 1 9.30
CHEMBL261121 1 7.46
CHEMBL261423 1 7.22
CHEMBL408448 1 6.76
CHEMBL409105 1 5.98
CHEMBL408182 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL408705 Ki = 0.3 nM 9.52
CHEMBL260273 Ki = 0.5 nM 9.30
CHEMBL261121 Ki = 35.0 nM 7.46
CHEMBL261423 Ki = 60.0 nM 7.22
CHEMBL408448 Ki = 175.0 nM 6.76
CHEMBL409105 Ki = 1050.0 nM 5.98
CHEMBL408182 Ki > 10000.0 nM -