Assay Detail
Binding
CHEMBL929342
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Inhibition of beta-secretase
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
In silico multi-filter screening approaches for developing novel beta-secretase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.23 | 7.82 |
| Ki | 1 | 7.58 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378225 | — | — | 1 | 7.82 |
| CHEMBL200077 | — | — | 1 | 7.58 |
| CHEMBL202602 | — | — | 1 | 7.01 |
| CHEMBL426717 | — | — | 1 | 5.85 |
| CHEMBL257137 | — | — | 1 | 5.30 |
| CHEMBL255924 | — | — | 1 | 5.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378225 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL200077 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL202602 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL426717 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL257137 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL255924 | — | IC50 | = | 7000.0 | nM | 5.16 |