Assay Detail
Binding
CHEMBL929352
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Inhibition of apamin-sensitive SK channel
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Bis-tetrahydroisoquinoline derivatives: AG525E1, a new step in the search for non-quaternary non-peptidic small conductance Ca(2+)-activated K(+) channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.78 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121663 | DEQUALINIUM CHLORIDE | 4.0 | 1 | 6.66 |
| CHEMBL257156 | — | — | 1 | 6.65 |
| CHEMBL402815 | — | — | 1 | 5.85 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | — | 1 | 5.80 |
| CHEMBL257803 | — | — | 1 | 5.72 |
| CHEMBL215382 | — | — | 1 | 5.24 |
| CHEMBL1407 | LAUDANOSINE | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121663 | DEQUALINIUM CHLORIDE | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL257156 | — | Ki | = | 223.0 | nM | 6.65 |
| CHEMBL402815 | — | Ki | = | 1422.0 | nM | 5.85 |
| CHEMBL215370 | LAUDANOSINE METHIODIDE | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL257803 | — | Ki | = | 1885.0 | nM | 5.72 |
| CHEMBL215382 | — | Ki | = | 5800.0 | nM | 5.24 |
| CHEMBL1407 | LAUDANOSINE | Ki | = | 30000.0 | nM | 4.52 |