Assay Detail
Functional
CHEMBL929489
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human CCR2 in PBMCs assessed as inhibition of chemotaxis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.52 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL271828 | — | — | 1 | 9.30 |
| CHEMBL273083 | — | — | 1 | 9.00 |
| CHEMBL270959 | — | — | 1 | 7.20 |
| CHEMBL270906 | — | — | 1 | 6.89 |
| CHEMBL411726 | — | — | 1 | 6.80 |
| CHEMBL272168 | — | — | 1 | 5.92 |
| CHEMBL272167 | — | — | 1 | - |
| CHEMBL429425 | — | — | 1 | - |
| CHEMBL411935 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL271828 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL273083 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL270959 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL270906 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL411726 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL272168 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL272167 | — | IC50 | - | — | - | |
| CHEMBL429425 | — | IC50 | - | — | - | |
| CHEMBL411935 | — | IC50 | - | — | - |