Assay Detail
Binding
CHEMBL929600
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Inhibition of human recombinant BACE1 by FRET assay
11
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Novel non-peptidic and small-sized BACE1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.67 | 8.92 |
| Activity | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439521 | — | — | 1 | 8.92 |
| CHEMBL183546 | — | — | 1 | 8.41 |
| CHEMBL381826 | — | — | 1 | 8.32 |
| CHEMBL183494 | — | — | 1 | 8.09 |
| CHEMBL378225 | — | — | 1 | 7.82 |
| CHEMBL42908 | — | — | 1 | 7.52 |
| CHEMBL400043 | — | — | 1 | 7.30 |
| CHEMBL399840 | — | — | 1 | 7.02 |
| CHEMBL399839 | — | — | 1 | 6.85 |
| CHEMBL253865 | — | — | 1 | 6.44 |
| CHEMBL413920 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439521 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL183546 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL381826 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL183494 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL378225 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL42908 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL400043 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL399840 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL399839 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL253865 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL413920 | — | Activity | - | — | - |