Assay Detail
Functional
CHEMBL929668
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of calcium ionophore-stimulated LTB4 production in human PMN cells
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PMN |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 7.87 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL255013 | — | — | 1 | 8.77 |
| CHEMBL558778 | — | — | 1 | 8.74 |
| CHEMBL255228 | — | — | 1 | 8.74 |
| CHEMBL401667 | — | — | 1 | 8.70 |
| CHEMBL401597 | — | — | 1 | 8.66 |
| CHEMBL254564 | — | — | 1 | 8.59 |
| CHEMBL541915 | — | — | 1 | 8.52 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.51 |
| CHEMBL403980 | — | — | 1 | 8.41 |
| CHEMBL255227 | — | — | 1 | 8.39 |
| CHEMBL254547 | — | — | 1 | 8.38 |
| CHEMBL404275 | — | — | 1 | 8.30 |
| CHEMBL404266 | — | — | 1 | 8.30 |
| CHEMBL256765 | — | — | 1 | 8.23 |
| CHEMBL404016 | — | — | 1 | 8.21 |
| CHEMBL402024 | — | — | 1 | 8.15 |
| CHEMBL254747 | — | — | 1 | 8.15 |
| CHEMBL256975 | — | — | 1 | 8.10 |
| CHEMBL438166 | — | — | 1 | 8.06 |
| CHEMBL256976 | — | — | 1 | 8.05 |
| CHEMBL401699 | — | — | 1 | 8.02 |
| CHEMBL404015 | — | — | 1 | 7.99 |
| CHEMBL256766 | — | — | 1 | 7.80 |
| CHEMBL258432 | — | — | 1 | 7.72 |
| CHEMBL415093 | — | — | 1 | 7.62 |
| CHEMBL403199 | — | — | 1 | 7.38 |
| CHEMBL401668 | — | — | 1 | 7.36 |
| CHEMBL255011 | — | — | 1 | 7.33 |
| CHEMBL258213 | — | — | 1 | 7.22 |
| CHEMBL257621 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL255013 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL558778 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL255228 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL401667 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL401597 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL254564 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL541915 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL403980 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL255227 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL254547 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL404275 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL404266 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL256765 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL404016 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL402024 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL254747 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL256975 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL438166 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL256976 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL401699 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL404015 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL256766 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL258432 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL415093 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL403199 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL401668 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL255011 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL258213 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL257621 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL255012 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL258215 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL258214 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL430038 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL404267 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL258431 | — | IC50 | = | 418.0 | nM | 6.38 |
| CHEMBL255010 | — | IC50 | > | 2372.0 | nM | - |
| CHEMBL257797 | — | IC50 | > | 1800.0 | nM | - |
| CHEMBL404276 | — | IC50 | < | 1.3 | nM | - |