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Assay Detail

CHEMBL929778

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Binding
Inhibition of hog gastric mucosa H/+K+ ATPase
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Porcula salvania
Tissue Gastric mucosa
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

5-Substituted 1H-pyrrolo[3,2-b]pyridines as inhibitors of gastric acid secretion.
Palmer AM, Münch G, Brehm C, Zimmermann PJ, Buhr W, Feth MP, Simon WA.
Bioorg Med Chem (2008) 16 : 1511 -1530
PubMed 17962023 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.67 6.90

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL402937 1 6.90
CHEMBL256398 2 6.80
CHEMBL271056 1 6.60
CHEMBL271855 1 6.10
CHEMBL403335 1 5.90
CHEMBL255322 1 5.70
CHEMBL256174 1 5.60
CHEMBL272501 1 5.50
CHEMBL255781 1 5.10
CHEMBL256175 1 5.00
CHEMBL257078 1 5.00
CHEMBL429750 1 4.80
CHEMBL271429 1 4.60
CHEMBL271640 1 4.60
CHEMBL401697 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL402937 IC50 = 125.89 nM 6.90
CHEMBL256398 IC50 = 160.0 nM 6.80
CHEMBL256398 IC50 = 158.49 nM 6.80
CHEMBL271056 IC50 = 251.19 nM 6.60
CHEMBL271855 IC50 = 794.33 nM 6.10
CHEMBL403335 IC50 = 1258.93 nM 5.90
CHEMBL255322 IC50 = 1995.26 nM 5.70
CHEMBL256174 IC50 = 2511.89 nM 5.60
CHEMBL272501 IC50 = 3162.28 nM 5.50
CHEMBL255781 IC50 = 7943.28 nM 5.10
CHEMBL256175 IC50 = 10000.0 nM 5.00
CHEMBL257078 IC50 = 10000.0 nM 5.00
CHEMBL429750 IC50 = 15848.93 nM 4.80
CHEMBL271429 IC50 = 25118.86 nM 4.60
CHEMBL271640 IC50 = 25118.86 nM 4.60
CHEMBL401697 IC50 < 100000.0 nM -