Assay Detail
Binding
CHEMBL929819
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Inhibition of human recombinant BACE1 by spectrofluorimetric method
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.86 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL239046 | — | — | 1 | 7.00 |
| CHEMBL271710 | — | — | 1 | 6.94 |
| CHEMBL248922 | — | — | 1 | 6.94 |
| CHEMBL271709 | — | — | 1 | 6.92 |
| CHEMBL407904 | — | — | 1 | 6.88 |
| CHEMBL272700 | — | — | 1 | 6.83 |
| CHEMBL270248 | — | — | 1 | 6.82 |
| CHEMBL26125 | — | — | 1 | 6.82 |
| CHEMBL244416 | — | — | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL239046 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL271710 | — | IC50 | = | 114.0 | nM | 6.94 |
| CHEMBL248922 | — | IC50 | = | 116.0 | nM | 6.94 |
| CHEMBL271709 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL407904 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL272700 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL270248 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL26125 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL244416 | — | IC50 | = | 238.0 | nM | 6.62 |