Assay Detail
Binding
CHEMBL930031
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Inhibition of human recombinant carboxylesterase 1 after 15 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.99 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273139 | — | — | 1 | 8.27 |
| CHEMBL270373 | — | — | 1 | 8.26 |
| CHEMBL89506 | — | — | 1 | 7.89 |
| CHEMBL86668 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273139 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL270373 | — | IC50 | = | 5.5 | nM | 8.26 |
| CHEMBL89506 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL86668 | — | IC50 | = | 30.0 | nM | 7.52 |