Assay Detail

CHEMBL930047

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Binding

Inhibition of rabbit liver carboxylesterase after 15 mins

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

Open DB target context

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Oryctolagus cuniculus
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).

Wheelock CE, Nishi K, Ying A, Jones PD, Colvin ME, Olmstead MM, Hammock BD.
Bioorg Med Chem (2008) 16 : 2114 -2130
PubMed 18023188 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	7.54	7.54

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL189886	BENZIL	—	1	7.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL189886	BENZIL	IC50	=	29.0	nM	7.54