Assay Detail
Binding
CHEMBL930242
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Binding affinity to Bcl-XL assessed as inhibition of Bcl-XL-BAD derived peptide interaction
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Bcl2-associated agonist of cell death (CHEMBL3817) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 9.22 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 9.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | Ki | = | 0.6 | nM | 9.22 |