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Assay Detail

CHEMBL930506

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human P2Y1 receptor
ChEMBL ↗
46
Total Activities
46
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

P2Y purinoceptor 1 (CHEMBL4315) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

P2Y1 receptor antagonists as novel antithrombotic agents.
Pfefferkorn JA, Choi C, Winters T, Kennedy R, Chi L, Perrin LA, Lu G, Ping YW, McClanahan T, Schroeder R, Leininger MT, Geyer A, Schefzick S, Atherton J.
Bioorg Med Chem Lett (2008) 18 : 3338 -3343
PubMed 18445527 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 45 6.71 9.11
Kd 1 6.96 6.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL444278 — — 1 9.11
CHEMBL255724 — — 1 8.00
CHEMBL255095 — — 1 7.70
CHEMBL256088 — — 1 7.52
CHEMBL256141 — — 1 7.52
CHEMBL258406 — — 1 7.30
CHEMBL257559 — — 1 7.22
CHEMBL402837 — — 1 7.22
CHEMBL255307 — — 1 7.16
CHEMBL255306 — — 1 7.05
CHEMBL256776 — — 1 7.00
CHEMBL129841 — — 1 6.96
CHEMBL255094 — — 1 6.92
CHEMBL256089 — — 1 6.92
CHEMBL403879 — — 1 6.89
CHEMBL402563 — — 1 6.89
CHEMBL255308 — — 1 6.85
CHEMBL255728 — — 1 6.82
CHEMBL255310 — — 1 6.75
CHEMBL404869 — — 1 6.70
CHEMBL257560 — — 1 6.60
CHEMBL255726 — — 1 6.60
CHEMBL257378 — — 1 6.57
CHEMBL403555 — — 1 6.54
CHEMBL401657 — — 1 6.25
CHEMBL402597 — — 1 6.16
CHEMBL255447 — — 1 6.12
CHEMBL255727 — — 1 6.02
CHEMBL258235 — — 1 5.92
CHEMBL258407 — — 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL444278 — Ki = 0.78 nM 9.11
CHEMBL255724 — Ki = 10.0 nM 8.00
CHEMBL255095 — Ki = 20.0 nM 7.70
CHEMBL256088 — Ki = 30.0 nM 7.52
CHEMBL256141 — Ki = 30.0 nM 7.52
CHEMBL258406 — Ki = 50.0 nM 7.30
CHEMBL257559 — Ki = 60.0 nM 7.22
CHEMBL402837 — Ki = 60.0 nM 7.22
CHEMBL255307 — Ki = 70.0 nM 7.16
CHEMBL255306 — Ki = 90.0 nM 7.05
CHEMBL256776 — Ki = 100.0 nM 7.00
CHEMBL129841 — Kd = 109.0 nM 6.96
CHEMBL256089 — Ki = 120.0 nM 6.92
CHEMBL255094 — Ki = 120.0 nM 6.92
CHEMBL402563 — Ki = 130.0 nM 6.89
CHEMBL403879 — Ki = 130.0 nM 6.89
CHEMBL255308 — Ki = 140.0 nM 6.85
CHEMBL255728 — Ki = 150.0 nM 6.82
CHEMBL255310 — Ki = 180.0 nM 6.75
CHEMBL404869 — Ki = 200.0 nM 6.70
CHEMBL257560 — Ki = 250.0 nM 6.60
CHEMBL255726 — Ki = 250.0 nM 6.60
CHEMBL257378 — Ki = 270.0 nM 6.57
CHEMBL403555 — Ki = 290.0 nM 6.54
CHEMBL401657 — Ki = 560.0 nM 6.25
CHEMBL402597 — Ki = 700.0 nM 6.16
CHEMBL255447 — Ki = 760.0 nM 6.12
CHEMBL255727 — Ki = 960.0 nM 6.02
CHEMBL258235 — Ki = 1200.0 nM 5.92
CHEMBL258407 — Ki = 1800.0 nM 5.75
CHEMBL430029 — Ki = 2700.0 nM 5.57
CHEMBL255505 — Ki = 4900.0 nM 5.31
CHEMBL255093 — Ki = 5200.0 nM 5.28
CHEMBL255278 — Ki = 7200.0 nM 5.14
CHEMBL256944 — Ki > 10000.0 nM -
CHEMBL256943 — Ki > 10000.0 nM -
CHEMBL258429 — Ki > 10000.0 nM -
CHEMBL428431 — Ki > 10000.0 nM -
CHEMBL257136 — Ki > 10000.0 nM -
CHEMBL258234 — Ki > 10000.0 nM -
CHEMBL255454 — Ki > 10000.0 nM -
CHEMBL255455 — Ki > 10000.0 nM -
CHEMBL403824 — Ki > 10000.0 nM -
CHEMBL402793 — Ki > 10000.0 nM -
CHEMBL255506 — Ki > 10000.0 nM -
CHEMBL255252 — Ki > 10000.0 nM -