Assay Detail
Binding
CHEMBL930527
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Inhibition of BACE1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.42 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL439521 | — | — | 1 | 8.92 |
| CHEMBL183546 | — | — | 1 | 8.41 |
| CHEMBL255838 | — | — | 1 | 8.25 |
| CHEMBL183494 | — | — | 1 | 8.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL439521 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL183546 | — | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL255838 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL183494 | — | IC50 | = | 8.2 | nM | 8.09 |