Assay Detail
Binding
CHEMBL930571
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Inhibition of GRE-mediated transcription in human HepG cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HepG |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structural analogs of tylophora alkaloids may not be functional analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.91 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL270213 | — | — | 1 | 8.00 |
| CHEMBL228286 | (-)-ANTOFINE | — | 1 | 7.62 |
| CHEMBL250426 | (S)-TYLOPHORINE | — | 1 | 6.64 |
| CHEMBL258137 | TYLOPHORINE | — | 1 | 6.27 |
| CHEMBL255848 | — | — | 1 | 5.61 |
| CHEMBL270214 | — | — | 1 | 5.35 |
| CHEMBL231290 | — | — | 1 | 5.14 |
| CHEMBL231192 | — | — | 1 | 5.04 |
| CHEMBL395994 | — | — | 1 | 4.72 |
| CHEMBL395996 | — | — | 1 | 4.68 |
| CHEMBL403878 | — | — | 1 | - |
| CHEMBL231193 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL270213 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL228286 | (-)-ANTOFINE | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL250426 | (S)-TYLOPHORINE | IC50 | = | 229.0 | nM | 6.64 |
| CHEMBL258137 | TYLOPHORINE | IC50 | = | 534.0 | nM | 6.27 |
| CHEMBL255848 | — | IC50 | = | 2440.0 | nM | 5.61 |
| CHEMBL270214 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL231290 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL231192 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL395994 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL395996 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL403878 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL231193 | — | IC50 | > | 30000.0 | nM | - |