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Assay Detail

CHEMBL930625

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to MMP2
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

72 kDa type IV collagenase (CHEMBL333)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Alpha,beta-cyclic-beta-benzamido hydroxamic acids: novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-alpha converting enzyme (TACE).
Ott GR, Asakawa N, Lu Z, Liu RQ, Covington MB, Vaddi K, Qian M, Newton RC, Christ DD, Traskos JM, Decicco CP, Duan JJ.
Bioorg Med Chem Lett (2008) 18 : 694 -699
PubMed 18061445 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 5.71 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL271235 1 5.96
CHEMBL256598 1 5.82
CHEMBL401979 1 5.77
CHEMBL256245 1 5.58
CHEMBL256805 1 5.56
CHEMBL401263 1 5.55
CHEMBL256621 1 -
CHEMBL439066 1 -
CHEMBL271234 1 -
CHEMBL404162 1 -
CHEMBL270800 1 -
CHEMBL441901 1 -
CHEMBL403401 1 -
CHEMBL429589 1 -
CHEMBL270606 1 -
CHEMBL270819 1 -
CHEMBL402746 1 -
CHEMBL235997 1 -
CHEMBL401824 1 -
CHEMBL257531 1 -
CHEMBL257532 1 -
CHEMBL438528 1 -
CHEMBL272341 1 -
CHEMBL256681 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL271235 Ki = 1100.0 nM 5.96
CHEMBL256598 Ki = 1500.0 nM 5.82
CHEMBL401979 Ki = 1700.0 nM 5.77
CHEMBL256245 Ki = 2633.0 nM 5.58
CHEMBL256805 Ki = 2733.0 nM 5.56
CHEMBL401263 Ki = 2800.0 nM 5.55
CHEMBL256621 Ki > 3333.0 nM -
CHEMBL439066 Ki > 3333.0 nM -
CHEMBL271234 Ki > 3333.0 nM -
CHEMBL404162 Ki > 3333.0 nM -
CHEMBL270800 Ki > 3333.0 nM -
CHEMBL441901 Ki > 3333.0 nM -
CHEMBL403401 Ki > 3333.0 nM -
CHEMBL429589 Ki > 3333.0 nM -
CHEMBL270606 Ki > 3333.0 nM -
CHEMBL270819 Ki > 3333.0 nM -
CHEMBL402746 Ki > 3333.0 nM -
CHEMBL235997 Ki > 3333.0 nM -
CHEMBL401824 Ki > 3333.0 nM -
CHEMBL257531 Ki > 3333.0 nM -
CHEMBL257532 Ki > 3333.0 nM -
CHEMBL438528 Ki > 3333.0 nM -
CHEMBL272341 Ki > 3333.0 nM -
CHEMBL256681 Ki > 3333.0 nM -