Assay Detail
Binding
CHEMBL930940
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Inhibition of TEM1 beta-lactamase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.19 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272130 | — | — | 1 | 8.92 |
| CHEMBL122450 | — | — | 1 | 8.85 |
| CHEMBL402221 | — | — | 1 | 8.72 |
| CHEMBL270810 | — | — | 1 | 8.62 |
| CHEMBL271238 | — | — | 1 | 8.55 |
| CHEMBL401578 | — | — | 1 | 8.40 |
| CHEMBL1744422 | — | — | 1 | 8.37 |
| CHEMBL403677 | — | — | 1 | 7.62 |
| CHEMBL1439 | TAZOBACTAM SODIUM | 4.0 | 1 | 7.00 |
| CHEMBL271723 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272130 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL122450 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL402221 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL270810 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL271238 | — | IC50 | = | 2.8 | nM | 8.55 |
| CHEMBL401578 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1744422 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL403677 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1439 | TAZOBACTAM SODIUM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL271723 | — | IC50 | = | 150.0 | nM | 6.82 |