Assay Detail
Binding
CHEMBL930987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]Tyr14-nociceptin from human NOP receptor expressed in HEK293 cells
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological evaluation of 1,2-dihydrospiro[isoquinoline-4(3H),4'-piperidin]-3-ones as nociceptin receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 28 | 7.37 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL396460 | NOCICEPTIN | — | 1 | 9.89 |
| CHEMBL412098 | — | — | 1 | 9.41 |
| CHEMBL272852 | — | — | 1 | 8.51 |
| CHEMBL271590 | — | — | 1 | 8.33 |
| CHEMBL409621 | — | — | 1 | 8.18 |
| CHEMBL272601 | — | — | 1 | 8.05 |
| CHEMBL270756 | — | — | 1 | 7.92 |
| CHEMBL272390 | — | — | 1 | 7.68 |
| CHEMBL407846 | — | — | 1 | 7.64 |
| CHEMBL412290 | — | — | 1 | 7.58 |
| CHEMBL272640 | — | — | 1 | 7.38 |
| CHEMBL272805 | — | — | 1 | 7.29 |
| CHEMBL449966 | — | — | 1 | 7.19 |
| CHEMBL259473 | — | — | 1 | 7.09 |
| CHEMBL272592 | — | — | 1 | 7.05 |
| CHEMBL272896 | — | — | 1 | 7.04 |
| CHEMBL271779 | — | — | 1 | 7.00 |
| CHEMBL271342 | — | — | 1 | 6.98 |
| CHEMBL271322 | — | — | 1 | 6.89 |
| CHEMBL259681 | — | — | 1 | 6.87 |
| CHEMBL407275 | — | — | 1 | 6.83 |
| CHEMBL271542 | — | — | 1 | 6.75 |
| CHEMBL270133 | — | — | 1 | 6.73 |
| CHEMBL406758 | — | — | 1 | 6.73 |
| CHEMBL271187 | — | — | 1 | 6.58 |
| CHEMBL272600 | — | — | 1 | 6.40 |
| CHEMBL271341 | — | — | 1 | 6.26 |
| CHEMBL271185 | — | — | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL396460 | NOCICEPTIN | Ki | = | 0.13 | nM | 9.89 |
| CHEMBL412098 | — | Ki | = | 0.39 | nM | 9.41 |
| CHEMBL272852 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL271590 | — | Ki | = | 4.7 | nM | 8.33 |
| CHEMBL409621 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL272601 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL270756 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL272390 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL407846 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL412290 | — | Ki | = | 26.0 | nM | 7.58 |
| CHEMBL272640 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL272805 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL449966 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL259473 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL272592 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL272896 | — | Ki | = | 92.0 | nM | 7.04 |
| CHEMBL271779 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL271342 | — | Ki | = | 104.0 | nM | 6.98 |
| CHEMBL271322 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL259681 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL407275 | — | Ki | = | 147.0 | nM | 6.83 |
| CHEMBL271542 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL270133 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL406758 | — | Ki | = | 186.0 | nM | 6.73 |
| CHEMBL271187 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL272600 | — | Ki | = | 395.0 | nM | 6.40 |
| CHEMBL271341 | — | Ki | = | 545.0 | nM | 6.26 |
| CHEMBL271185 | — | Ki | = | 740.0 | nM | 6.13 |