Assay Detail
Functional
CHEMBL931094
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at dopamine D3 receptor by GTPgammaS binding assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part 2: [g]-fused and hetero-fused systems.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 36 | 7.89 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL402215 | — | — | 1 | 9.10 |
| CHEMBL437792 | — | — | 1 | 9.10 |
| CHEMBL271034 | — | — | 1 | 9.00 |
| CHEMBL244946 | — | — | 1 | 8.80 |
| CHEMBL271449 | — | — | 1 | 8.80 |
| CHEMBL256488 | — | — | 1 | 8.70 |
| CHEMBL256442 | — | — | 1 | 8.70 |
| CHEMBL272775 | — | — | 1 | 8.60 |
| CHEMBL270387 | — | — | 1 | 8.50 |
| CHEMBL85606 | — | — | 1 | 8.40 |
| CHEMBL272150 | — | — | 1 | 8.40 |
| CHEMBL404404 | — | — | 1 | 8.40 |
| CHEMBL402853 | — | — | 1 | 8.40 |
| CHEMBL404363 | — | — | 1 | 8.30 |
| CHEMBL270376 | — | — | 1 | 8.30 |
| CHEMBL270602 | — | — | 1 | 8.20 |
| CHEMBL403804 | — | — | 1 | 8.20 |
| CHEMBL442456 | — | — | 1 | 8.10 |
| CHEMBL427836 | — | — | 1 | 7.90 |
| CHEMBL255158 | — | — | 1 | 7.80 |
| CHEMBL256659 | — | — | 1 | 7.70 |
| CHEMBL272297 | — | — | 1 | 7.60 |
| CHEMBL271909 | — | — | 1 | 7.50 |
| CHEMBL272511 | — | — | 1 | 7.20 |
| CHEMBL402422 | — | — | 1 | 7.00 |
| CHEMBL257717 | — | — | 1 | 6.80 |
| CHEMBL271729 | — | — | 1 | 6.80 |
| CHEMBL272588 | — | — | 1 | 6.70 |
| CHEMBL411293 | — | — | 1 | 6.60 |
| CHEMBL403815 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL402215 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL437792 | — | Ki | = | 0.7943 | nM | 9.10 |
| CHEMBL271034 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL244946 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL271449 | — | Ki | = | 1.585 | nM | 8.80 |
| CHEMBL256488 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL256442 | — | Ki | = | 1.995 | nM | 8.70 |
| CHEMBL272775 | — | Ki | = | 2.512 | nM | 8.60 |
| CHEMBL270387 | — | Ki | = | 3.162 | nM | 8.50 |
| CHEMBL272150 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL402853 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL404404 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL85606 | — | Ki | = | 3.981 | nM | 8.40 |
| CHEMBL404363 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL270376 | — | Ki | = | 5.012 | nM | 8.30 |
| CHEMBL270602 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL403804 | — | Ki | = | 6.31 | nM | 8.20 |
| CHEMBL442456 | — | Ki | = | 7.943 | nM | 8.10 |
| CHEMBL427836 | — | Ki | = | 12.59 | nM | 7.90 |
| CHEMBL255158 | — | Ki | = | 15.85 | nM | 7.80 |
| CHEMBL256659 | — | Ki | = | 19.95 | nM | 7.70 |
| CHEMBL272297 | — | Ki | = | 25.12 | nM | 7.60 |
| CHEMBL271909 | — | Ki | = | 31.62 | nM | 7.50 |
| CHEMBL272511 | — | Ki | = | 63.1 | nM | 7.20 |
| CHEMBL402422 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL257717 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL271729 | — | Ki | = | 158.49 | nM | 6.80 |
| CHEMBL272588 | — | Ki | = | 199.53 | nM | 6.70 |
| CHEMBL411293 | — | Ki | = | 251.19 | nM | 6.60 |
| CHEMBL403815 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL271511 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL271702 | — | Ki | = | 794.33 | nM | 6.10 |
| CHEMBL256658 | — | Ki | < | 251.19 | nM | - |
| CHEMBL257716 | — | Ki | < | 251.19 | nM | - |
| CHEMBL255220 | — | Ki | < | 125.89 | nM | - |
| CHEMBL406678 | — | Ki | < | 251.19 | nM | - |