Assay Detail
Binding
CHEMBL931109
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Displacement of [3H]DTG from sigma 2 receptor in rat liver membrane
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Tritium radiolabelling of PB28, a potent sigma-2 receptor ligand: pharmacokinetic and pharmacodynamic characterization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.38 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53325 | — | — | 1 | 9.47 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.13 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53325 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 7.38 | nM | 8.13 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 28.2 | nM | 7.55 |