Assay Detail
Functional
CHEMBL931166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum 3D7
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 7.13 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL272033 | — | — | 1 | 8.57 |
| CHEMBL272199 | — | — | 1 | 8.44 |
| CHEMBL99254 | — | — | 1 | 8.35 |
| CHEMBL406401 | — | — | 1 | 8.12 |
| CHEMBL1630 | — | — | 1 | 8.01 |
| CHEMBL272416 | — | — | 1 | 7.99 |
| CHEMBL410726 | — | — | 1 | 7.91 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.82 |
| CHEMBL271825 | — | — | 1 | 7.69 |
| CHEMBL146617 | — | — | 1 | 7.67 |
| CHEMBL407948 | — | — | 1 | 7.64 |
| CHEMBL408001 | — | — | 1 | 7.64 |
| CHEMBL269854 | — | — | 1 | 7.62 |
| CHEMBL260741 | — | — | 1 | 7.50 |
| CHEMBL261168 | — | — | 1 | 7.28 |
| CHEMBL259475 | — | — | 1 | 7.08 |
| CHEMBL269917 | — | — | 1 | 6.89 |
| CHEMBL411132 | — | — | 1 | 6.84 |
| CHEMBL270126 | — | — | 1 | 6.83 |
| CHEMBL272857 | — | — | 1 | 6.81 |
| CHEMBL270773 | — | — | 1 | 6.79 |
| CHEMBL270522 | — | — | 1 | 6.74 |
| CHEMBL271176 | — | — | 1 | 6.74 |
| CHEMBL270316 | — | — | 1 | 6.74 |
| CHEMBL271781 | — | — | 1 | 6.64 |
| CHEMBL259886 | — | — | 1 | 6.62 |
| CHEMBL272012 | — | — | 1 | 6.54 |
| CHEMBL272013 | — | — | 1 | 6.50 |
| CHEMBL270763 | — | — | 1 | 6.29 |
| CHEMBL273125 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL272033 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL272199 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL99254 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL406401 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL1630 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL272416 | — | IC50 | = | 10.2 | nM | 7.99 |
| CHEMBL410726 | — | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL271825 | — | IC50 | = | 20.6 | nM | 7.69 |
| CHEMBL146617 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL407948 | — | IC50 | = | 22.7 | nM | 7.64 |
| CHEMBL408001 | — | IC50 | = | 22.8 | nM | 7.64 |
| CHEMBL269854 | — | IC50 | = | 23.7 | nM | 7.62 |
| CHEMBL260741 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL261168 | — | IC50 | = | 52.8 | nM | 7.28 |
| CHEMBL259475 | — | IC50 | = | 83.7 | nM | 7.08 |
| CHEMBL269917 | — | IC50 | = | 127.5 | nM | 6.89 |
| CHEMBL411132 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL270126 | — | IC50 | = | 146.4 | nM | 6.83 |
| CHEMBL272857 | — | IC50 | = | 155.7 | nM | 6.81 |
| CHEMBL270773 | — | IC50 | = | 162.1 | nM | 6.79 |
| CHEMBL270522 | — | IC50 | = | 182.9 | nM | 6.74 |
| CHEMBL271176 | — | IC50 | = | 183.8 | nM | 6.74 |
| CHEMBL270316 | — | IC50 | = | 183.9 | nM | 6.74 |
| CHEMBL271781 | — | IC50 | = | 229.4 | nM | 6.64 |
| CHEMBL259886 | — | IC50 | = | 237.2 | nM | 6.62 |
| CHEMBL272012 | — | IC50 | = | 288.8 | nM | 6.54 |
| CHEMBL272013 | — | IC50 | = | 318.7 | nM | 6.50 |
| CHEMBL270763 | — | IC50 | = | 517.2 | nM | 6.29 |
| CHEMBL273125 | — | IC50 | = | 993.9 | nM | 6.00 |
| CHEMBL410129 | — | IC50 | = | 6438.0 | nM | 5.19 |
| CHEMBL269855 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL112 | ACETAMINOPHEN | IC50 | > | 198400.0 | nM | - |