Assay Detail

CHEMBL931243

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Functional

Cytotoxicity against human PC6 cells

ChEMBL ↗

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Target

PC-6 (CHEMBL614235) ↗

Open DB target context

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Primary target PC-6

CHEMBL614235

Anchored from Assay target.

Protein identity PC-6

Disease frame Disease evidence pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	PC-6
Confidence	1 — Organism
Curated By	Autocuration

Target

PC-6 (CHEMBL614235) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis of new benzimidazole linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates with efficient DNA-binding affinity and potent cytotoxicity.

Kamal A, Kumar PP, Sreekanth K, Seshadri BN, Ramulu P.
Bioorg Med Chem Lett (2008) 18 : 2594 -2598
PubMed 18378445 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.48	6.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL293096	—	—	1	6.48

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL293096	—	IC50	=	330.0	nM	6.48