Assay Detail
Functional
CHEMBL931258
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against EP3 receptor by FLIPR assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP3 subtype (CHEMBL3710) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.33 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL257997 | — | — | 1 | 6.50 |
| CHEMBL257134 | — | — | 1 | 6.40 |
| CHEMBL255675 | — | — | 1 | 6.40 |
| CHEMBL403407 | — | — | 1 | 6.30 |
| CHEMBL402392 | — | — | 1 | 6.30 |
| CHEMBL254763 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL257997 | — | Ki | = | 316.23 | nM | 6.50 |
| CHEMBL257134 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL255675 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL403407 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL402392 | — | Ki | = | 501.19 | nM | 6.30 |
| CHEMBL254763 | — | Ki | = | 794.33 | nM | 6.10 |