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Assay Detail

CHEMBL931373

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Trypanosoma cruzi hexokinase in presence of D-glucose, 1 mM ATP and 3 mM MgCl2
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Trypanosoma cruzi
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Hexokinase (CHEMBL4151)
Type SINGLE PROTEIN
Organism Trypanosoma cruzi

Publication

Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies.
Sanz-Rodríguez CE, Concepción JL, Pekerar S, Oldfield E, Urbina JA.
J Biol Chem (2007) 282 : 12377 -12387
PubMed 17329254 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.22 5.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL55886 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL55886 Ki = 6000.0 nM 5.22