Assay Detail
Functional
CHEMBL931442
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Cytotoxicity against human AGS cells by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | AGS |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Hypoxia-inducible factor-1 and nuclear factor-kappaB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.61 | 4.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262344 | BAKUCHIOL | 1.0 | 1 | 4.82 |
| CHEMBL383824 | ALVESPIMYCIN | 2.0 | 1 | 4.80 |
| CHEMBL408851 | ACETYLBAKUCHIOL | — | 1 | 4.57 |
| CHEMBL262630 | — | — | 1 | 4.25 |
| CHEMBL261315 | — | — | 1 | - |
| CHEMBL260776 | — | — | 1 | - |
| CHEMBL405046 | — | — | 1 | - |
| CHEMBL258478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262344 | BAKUCHIOL | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL383824 | ALVESPIMYCIN | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL408851 | ACETYLBAKUCHIOL | IC50 | = | 26800.0 | nM | 4.57 |
| CHEMBL262630 | — | IC50 | = | 55800.0 | nM | 4.25 |
| CHEMBL261315 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL260776 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL405046 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL258478 | — | IC50 | > | 50000.0 | nM | - |