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Assay Detail

CHEMBL931459

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]valsartan from human AT1 receptor expressed in CHO cells
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Type-1 angiotensin II receptor (CHEMBL227)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Beta-homo-amino acid scan of angiotensin IV.
Lukaszuk A, Demaegdt H, Szemenyei E, Tóth G, Tymecka D, Misicka A, Karoyan P, Vanderheyden P, Vauquelin G, Tourwé D.
J Med Chem (2008) 51 : 2291 -2296
PubMed 18386881 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Activity 4 - -
Ki 2 6.33 6.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL261120 ANGIOTENSIN IV 1 6.39
CHEMBL260622 1 6.26
CHEMBL408871 1 -
CHEMBL261422 1 -
CHEMBL259019 1 -
CHEMBL248592 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL261120 ANGIOTENSIN IV Ki = 407.38 nM 6.39
CHEMBL260622 Ki = 549.54 nM 6.26
CHEMBL408871 Activity - -
CHEMBL261422 Activity - -
CHEMBL259019 Activity - -
CHEMBL248592 Activity - -