Assay Detail
Binding
CHEMBL931480
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Displacement of [3H]EPI from Aplysia AChBP expressed in HEK293S cells by scintillation proximity assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Aplysia |
| Cell Type | HEK293S |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Mapping the elusive neonicotinoid binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 7.44 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL95904 | — | — | 1 | 8.77 |
| CHEMBL451432 | THIACLOPRID | — | 1 | 8.08 |
| CHEMBL6623 | EPIBATIDINE | — | 1 | 8.07 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | — | 1 | 8.07 |
| CHEMBL265941 | ACETAMIPRID | — | 1 | 7.72 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | — | 1 | 7.36 |
| CHEMBL259728 | NITENPYRAM | — | 1 | 6.75 |
| CHEMBL406819 | IMIDACLOPRID | — | 1 | 6.75 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 6.58 |
| CHEMBL259727 | CLOTHIANIDINE | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95904 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL451432 | THIACLOPRID | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL6623 | EPIBATIDINE | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL71046 | DESCYANOTHIACLOPRID | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL265941 | ACETAMIPRID | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL309804 | DESNITROIMIDACLOPRID | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL259728 | NITENPYRAM | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL406819 | IMIDACLOPRID | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL3 | NICOTINE | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL259727 | CLOTHIANIDINE | Ki | = | 574.0 | nM | 6.24 |