Assay Detail
Binding
CHEMBL931720
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Inhibition of human PNP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.81 | 10.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269864 | ULODESINE | 2.0 | 1 | 10.97 |
| CHEMBL407776 | — | — | 1 | 9.64 |
| CHEMBL269866 | — | — | 1 | 9.59 |
| CHEMBL270904 | — | — | 1 | 8.20 |
| CHEMBL405926 | — | — | 1 | 7.89 |
| CHEMBL271387 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269864 | ULODESINE | Ki | = | 0.0107 | nM | 10.97 |
| CHEMBL407776 | — | Ki | = | 0.229 | nM | 9.64 |
| CHEMBL269866 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL270904 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL405926 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL271387 | — | Ki | = | 280.0 | nM | 6.55 |