Assay Detail
Binding
CHEMBL931722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Plasmodium falciparum PNP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Purine nucleoside phosphorylase (CHEMBL5648) ↗| Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum |
Publication
Azetidine based transition state analogue inhibitors of N-ribosyl hydrolases and phosphorylases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.04 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269864 | ULODESINE | 2.0 | 1 | 9.30 |
| CHEMBL269866 | — | — | 1 | 6.72 |
| CHEMBL271387 | — | — | 1 | 6.24 |
| CHEMBL405926 | — | — | 1 | 5.89 |
| CHEMBL407776 | — | — | 1 | - |
| CHEMBL270904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269864 | ULODESINE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL269866 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL271387 | — | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL405926 | — | Ki | = | 1290.0 | nM | 5.89 |
| CHEMBL407776 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL270904 | — | Ki | > | 10000.0 | nM | - |